By Monday I'll Be Floating in the Hudson with the Other Garbage by Laura Lannes, $25. Oversize, riso printed. 

This was the first comic I saw by Lannes, and I don't think I've ever read a story by someone whose work I was just encountering for the first time that was this strong. Lannes isn't just an extrmely skilled storyteller, her work is genuinely funny and painful as well. If you're looking for a comic that is both extremely readable and uncompromisingly artistic, this is the one.